Top Billed Cast

1. 

   Chris Rock

   Osmosis Jones (voice)

2. 

   Laurence Fishburne

   Thrax (voice)

3. 

   David Hyde Pierce

   Drix (voice)

4. 

   Brandy Norwood

   Leah (voice)

5. 

   Bill Murray

   Frank Detorre

6. 

   Molly Shannon

   Mrs. Boyd

7. 

   William Shatner

   Mayor Phlegmming (voice)

8. 

   Ron Howard

   Tom Colonic (voice)

9. 

   Sherry Lynn

   (voice)

10. 

    Mickie McGowan

    Additional Character Voice (voice)

11. 

    Chris Elliott

    Bob

12. 

    Elena Franklin

    Shane Detorre

13. 

    Kid Rock

    Kidney Rock

14. 

    Uncle Kracker

    Kidney Rock (voice)

15. 

    Carlos Alazraqui

    Additional Character Voices (voice)

16. 

    Rodger Bumpass

    Additional Character Voices (voice)

17. 

    Richard Steven Horvitz

    Additional Character Voices (voice)

18. 

    Danny Mann

    Additional Character Voices (voice)

19. 

    Mickie McGowan

    Additional Character Voices (voice)

20. 

    Jonathan Adams

    Additional Character Voices (voice)