Top Billed Cast

1. 

   Gena Rowlands

   Ivy

2. 

   Tony Shalhoub

   Misha Vilyenkov

3. 

   Cheech Marin

   Ignacio

4. 

   Bruce Davison

   Dr. Reingold

5. 

   Trini Alvarado

   Adult Marie Alweather

6. 

   Jay Mohr

   Benny / Paulie (voice)

7. 

   Buddy Hackett

   Artie

8. 

   Hallie Eisenberg

   Marie Alweather

9. 

   Matt Craven

   Warren Alweather

10. 

    Bill Cobbs

    Virgil the Janitor

11. 

    Tia Texada

    Ruby / Lupe (voice)

12. 

    Laura Harrington

    Lila Alweather

13. 

    Peter Basch

    Graduate Student #1

14. 

    Emily Mura-Smith

    Graduate Student #2

15. 

    Hal Robinson

    Grandpa

16. 

    Tamara Zook

    Speech Therapist

17. 

    Nicole Chamberlain

    Shirley

18. 

    Charles Parks

    Gerald

19. 

    Seth Mumy

    Jeremy

20. 

    Dig Wayne

    Research Assistant #1

21. 

    Michael Leydon Campbell

    Research Assistant #2

22. 

    Kristie Transeau

    Veterinarian

23. 

    Francesca Federico-O'Murchu

    Molly

24. 

    Jerry Winsett

    Mr. Tauper

25. 

    Bud Cox

    Ivy's Doctor

26. 

    Josh Cruze

    Cantina Singer