Series Cast
Christina Applegate
Samantha Newly
Jennifer Esposito
Andrea Belladonna
Kevin Dunn
Howard
Melissa McCarthy
Dena
Tim Russ
Frank
Barry Watson
Todd
Jean Smart
Regina Newly
Current Season

Season 2
2008 | 20 Episodes
Season 2 of Samantha Who? premiered on Oct 13 2008
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Facts
Status
Canceled
Status

Type
Scripted
Original Language
English
Keywords
- memory loss
- good deed